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The standard model of synaptic consolidation suggests that alterations of synaptic protein synthesis and changes in membrane potential are achieved through activating intracellular transduction cascades.These molecular cascades trigger transcription factors that lead to changes in gene expression.
Disruptions caused by specific drugs, antibodies and gross physical trauma can block the effects of synaptic consolidation.
and is known to produce increases in the neurotransmitter production and receptor sensitivity, lasting minutes to even days.
The two proposed the perseveration-consolidation hypothesis after they found that new information learned could disrupt information previously learnt if not enough time had passed to allow the old information to be consolidated.
Systematic studies of anterograde amnesia started to emerge in the 1960s and 1970s.
After Molaison underwent a bilateral medial temporal lobe resection to alleviate epileptic symptoms the patient began to suffer from memory impairments.